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Home > Drug Category > Cholesterol Medications > Nexlizet and Equivalent

Nexlizet Information

Nexlizet (Bempedoic acid - Ezetimibe) is a combination medication used along with a proper diet and other medications to help lower bad cholesterol (such as Low-density Lipoprotein) in the blood in conditions like heterozygous familial hypercholesterolemia (HeFH). It is also used in people with known heart disease who need additional lowering of bad cholesterol levels. Bempedoic acid belongs to adenosine triphosphate-citrate lyase inhibitors. It works by reducing the amount of cholesterol made by the liver through inhibition of cholesterol synthesis in the liver and absorption in the intestine. Ezetimibe is a cholesterol absorption inhibitor that works by reducing the amount of cholesterol the body absorbs from the diet.

Nexlizet Side Effects

The most common side effects of Nexlizet include symptoms of the common cold, flu, or flu-like symptoms, back pain, bronchitis, anemia, diarrhea, urinary tract infection (UTI), constipation, sinus infections, tiredness, pain in your mouth, back, joints, arms, or legs muscle spasms, stomach pain, increased liver enzymes, and fatigue.

Nexlizet may cause serious side effects, inform your doctor at once if you notice the following:
• Bruising right after an injury in a tendon area;
• Hear or feel a snap or pop in a tendon area;
• Joint redness;
• Increased levels of uric acid in your blood (hyperuricemia);
• Mild changes in blood test results, (such as increased liver enzymes or anemia (low level of red blood cells);
• Tender joints;
• Severe foot pain especially in the toe joint;
• Swelling;
• Warm joints.

Nexlizet Precautions

Do not take Nexlizet if you are allergic to ezetimibe tablets. Ezetimibe, one of the ingredients in Nexlizet, can cause serious allergic reactions. Before using Nexlizet, be sure to tell your doctor about all medications you take, including prescription and over-the-counter types. Also describe any vitamins, herbs, or supplements you are using. Inform your doctor before using Nexlizet if you take or plan to take:
• A corticosteroid (such as prednisone);
• Cholestyramine (another cholesterol-lowering medicine);
• Cyclosporine (often used in organ transplant patients);
• Fibrates;
• Fluoroquinolone antibiotics (such as ciprofloxacin);
• Simvastatin or pravastatin (other cholesterol-lowering medicines).

Do not use it for a long period except instructed to do so. Follow your doctor's exercise and diet routine effectively. Talk to your doctor or pharmacist if you are allergic to bempedoic acid or ezetimibe; or if you have any other allergies. Do not use Nexlizet if you are above 60 years of age. Do not take Nexlizet while pregnant or breastfeeding; it may cause harmful effects in a developing fetus or a breastfed child. Nexlizet may contain inactive ingredients, which can cause allergic reactions or other problems. Also, talk to your doctor about your medical history, if you;
• Have or had arthritis;
• Have or had gout;
• Have or had tendon problems;
• Have severe kidney problems;
• Have moderate or severe liver problems.

Do I need a prescription to order Nexlizet?

Yes, a prescription is required from your physician to order Nexlizet.