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Home > Drug Category > Endometriosis Medication > Orilissa and Equivalent

Orilissa Information

Orilissa (Elagolix Sodium) is used to help women relieve moderate to severe pain due to endometriosis. Endometriosis is a condition where the tissue that usually lines the inside of the womb (uterus) grows in a different place. This tissue may grow outside the surface of the uterus, on the ovaries, or other organs. This condition may cause symptoms such as infertility, painful sex, or painful menstrual periods. Gonadotropin-releasing hormone (GnRH) receptor antagonists like Elagolix decrease the body’s production of luteinizing hormone to reduce the amount of female sex hormones in the body. Lower hormone levels may help decrease symptoms of endometriosis.

Orilissa Side Effects

The most common side effects of Orilissa may include nausea, hot flashes, headaches, and sleeping difficulties. Call your doctor right away if you have any of the severe side effects, such as:
• Mood changes;
• Signs of an allergic reaction such as hives, breathing difficulties, swelling of the face, tongue, or throat;
• Signs of liver problems such as nausea, vomiting, easy bruising, tiredness

Orilissa Precautions

Do not use Orilissa if you are allergic to Elagolix Sodium or other ingredients in this medication. Before you start using this medication, tell your doctor about your medical history, including if you have osteoporosis, severe liver disease, depression, suicidal thoughts, think you may be pregnant or plan to become pregnant, are breastfeeding, or are planning to breastfeed. Tell your doctor about all your medications, including prescription, OTC, herbal supplements, and vitamins. There may be a drug interaction between Orilissa and other medications, like birth control pills, cyclosporine, ritonavir, and gemfibrozil. Do not use Orilissa if you are pregnant or planning to become pregnant without informing your doctor. Elagolix may cause miscarriage. Avoid using hormonal birth control pills to prevent pregnancy. They may make Orilissa less effective. Use condoms or diaphragm with spermicide to prevent pregnancy while using the drug and for at least one week after your last dose. Orilissa may change your menstrual periods, making it harder for you to know when you are pregnant. Do not use Orilissa while breastfeeding without talking to your doctor. It is unknown if Elagolix Sodium passes into your breastmilk or if it may harm nursing infants. It is unknown if this drug is safe for use in children. Use your medicine exactly as prescribed by your doctor. Take this drug by mouth, with or without food. Take the drug at the same time each day to help you remember. Orilissa can lower your estrogen levels and cause bone loss. Talk to your doctor about how to keep your bones healthy during and after treatment. Store this medication at room temperature and keep it out of the reach of children.

Do I need a prescription to order Orilissa?

Yes, a prescription is required from your physician to order Orilissa.