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Home > Drug Category > Psychiatric Medication > Seroquel XR and Equivalent

Seroquel XR (Quetiapine fumarate extended release 24HR) Information

Seroquel XR, which contains the active ingredient quetiapine fumarate extended release 24HR, is an atypical antipsychotic. It is used to treat schizophrenia, bipolar disorder (including manic, mixed, and depressive episodes), and as an additional therapy for major depressive disorder in adults. In schizophrenia, it helps reduce hallucinations, delusions, and disorganized thoughts. In bipolar disorder, it stabilizes mood, reduces mania, and alleviates depressive symptoms. Seroquel XR is taken once a day, usually in the evening, and is designed to release the medication steadily over 24 hours, providing smoother, all-day symptom control.

The mechanism of action of quetiapine involves blocking dopamine (D2) and serotonin (5-HT2A) receptors, helping rebalance chemical pathways that influence mood, perception, and behavior. It also affects histamine and adrenergic receptors, contributing to its calming effects and improvements in sleep. The extended-release formulation delivers the medication gradually, supporting consistent symptom control, reducing sharp peaks in blood levels, and lowering the chance of peak-related side effects such as sudden sedation or dizziness.

Seroquel XR Side Effects

Seroquel XR is generally well-tolerated, but some common side effects may occur. Common side effects include sleepiness or drowsiness, dizziness, dry mouth, constipation, increased appetite, and weight gain. Some people may experience headaches, mild drops in blood pressure when standing, or difficulty sleeping during the first days of treatment. Children and adolescents may be more likely to experience increased appetite, fatigue, or irritability.

More serious side effects can occur, leading to significant monitoring protocols. If you experience any of the following symptoms, seek immediate medical attention:
• Irregular heartbeat, fainting, or severe dizziness
• Seizures
• Signs of high blood sugar, including excessive thirst, frequent urination, and confusion
• Signs of Neuroleptic Malignant Syndrome (NMS), including high fever, muscle stiffness, confusion, sweating, and fast heartbeat
• Signs of severe allergic reactions, including swelling of the face, lips, or throat, difficulty breathing, rash
• Signs of Tardive Dyskinesia (TD), including involuntary movements of the face, lips, tongue, or limbs
• Sudden changes in mood, worsening depression, or suicidal thoughts

Seroquel XR Precautions

Do not use Seroquel XR if you are allergic to quetiapine or any ingredients in the medication. Before starting treatment, inform your doctor of your complete medical history. People with heart disease, low blood pressure, a history of stroke, diabetes, high cholesterol, liver disease, seizures, or movement disorders may require additional monitoring. Because the medication can affect weight, cholesterol, and blood sugar, your doctor may recommend regular check-ups. Seroquel XR should not be used in older adults with dementia-related psychosis due to an increased risk of death.

Tell your doctor about all medications, supplements, or herbal products you take. Seroquel XR can interact with antidepressants, antipsychotics, blood pressure medications, seizure medications, certain antibiotics, antifungals, and drugs that affect liver enzymes. Avoid alcohol and other sedatives, as they may increase drowsiness and impair coordination. Inform your doctor if you are pregnant or planning to become pregnant. Taking Seroquel XR late in pregnancy may cause breathing difficulties or muscle stiffness in newborns. Inform your doctor if you are breastfeeding. Small amounts of quetiapine can pass into breast milk. Take Seroquel XR exactly as prescribed, once daily, usually in the evening. Take Seroquel XR without food or with a light meal. Avoid taking it with a high-fat meal, as this causes the body to absorb too much medication at once. Swallow the extended-release tablets whole. Do not crush, split, or chew them. Take the medicine at the same time each day to maintain stable medication levels. Do not stop taking Seroquel XR abruptly unless directed by your doctor. Stopping the medicine suddenly may lead to withdrawal symptoms or a return of your condition. Store the medication at room temperature, away from heat, moisture, and light, and keep it out of reach of children.

Do I need a prescription to order Seroquel XR?

Yes, a prescription is required from your physician to order Seroquel XR.